| Theme | Ectopic calcification on soft tissue: Vascular calcification and cardiac valvular calcification | |
|---|---|---|
| Title | Vascular calcification, vitamin D, and hormones in chronic kidney disease | |
| Publish Date | 2019/10 | |
| Author | Takayasu Ohtake | Kidney and Transplant Center, Shonan Kamakura General Hospital |
| Author | Shuzo Kobayashi | Kidney and Transplant Center, Shonan Kamakura General Hospital |
| [ Summary ] | Both vascular endothelial cell damage and medial calcification form the characteristic features. of atherosclerosis in patients with chronic kidney disease (CKD). It constitutes the advanced "vascular failure" in CKD patients. Not only the passive process of calcium/phosphate precipitation in the vascular wall, but also the active process of vascular smooth muscle cells to osteoblastic-like cells transition due to the accumulation of uremic toxins and phosphate are related to vascular calcification. Vascular calcification is associated with several mineral-bone regulating hormones including vitamin D, intact parathyroid hormone, and fibroblast growth factor 23. | |