| Theme | Endocrinological control of bone metabolism | |
|---|---|---|
| Title | Roles of osteocrin and C-type naturiuretic peptide in bone growth | |
| Publish Date | 2019/04 | |
| Author | Akihiro Yasoda | Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine |
| Author | Yugo Kanai | Department of Diabetes and Endocrinology, Osaka Red Cross Hospital |
| [ Summary ] | Natriuretic peptide receptor-B (NPR-B) mediates the biological actions of C-type natriuretic peptide (CNP), whereas natriuretic peptide receptor-C (NPR-C) is engaged in the clearance of natriuretic peptides including CNP. CNP potently stimulates the growth of bones formed through endochondral ossification via NPR-B. Recent studies revealed that osteocrin, an endogenous and specific ligand for NPR-C, stimulates endochondral bone growth by increasing CNP levels by binding to NPR-C and interfering the clearance of CNP. Modulation of NPR-C by osteocrin or its analogues might be a novel strategy in regulating the CNP/NPR-B system, of which activation is expected to be a new therapy for impaired skeletal growth. | |