| Theme | Endocrinological control of bone metabolism | |
|---|---|---|
| Title | The regulation of bone metabolism from the perspective of calcium and phosphate metabolism -- Fibroblast growth factor 23 | |
| Publish Date | 2019/04 | |
| Author | Yuichi Takashi | Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University |
| [ Summary ] | Fibroblast growth factor (FGF) 23 is a bone-derived hormone, which has a pivotal role in regulating phosphate metabolism. Phosphate is one of the components of hydroxyapatite and essential for bone mineralization. Excessive action of FGF23 causes hypophosphatemia and rickets/osteomalacia. In contrast, impaired FGF23 action causes hyperphosphatemia and tumoral calcinosis. Furthermore, FGF23 starts to increase in the early stage of chronic kidney disease (CKD) and contributes to the progression of CKD-mineral and bone disorder (CKDMBD). Therefore, the regulation of phosphate metabolism by FGF23 is essential for healthy bone metabolism. New therapeutic medicine for FGF23-related hypophosphatemic rickets/osteomalacia has been developed. The progress of research and development concerning FGF23 is remarkable. | |