| Theme | Endocrinological control of bone metabolism | |
|---|---|---|
| Title | Roles of androgens in bone metabolism | |
| Publish Date | 2019/04 | |
| Author | Yuuki Imai | Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University / Department of Pathophysiology, Graduate School of Medicine, Ehime University / Division of Laboratory Animal Research, Advanced Research Support Center, Ehime University |
| [ Summary ] | Androgens bind to their specific receptor, androgen receptor (AR), and liganded ARs play roles in the regulation of transcription for target genes to maintain homeostasis. Testosterone, one of the androgens, can be converted to both DHT as a strong AR ligand by 5α-reductase and E2 as an ER ligand by aromatase. To understand androgens' functions in bone homeostasis, we should consider the roles of androgen/AR and estrogen/ER signaling. | |