| Theme | New frontiers of calcimimetics | |
|---|---|---|
| Title | Structure and function of calcium-sensing receptor | |
| Publish Date | 2018/09 | |
| Author | Seiji Fukumoto | Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University |
| [ Summary ] | Calcium-sensing receptor (CaSR) is one of G-protein coupled receptors which has a pivotal role in the regulation of parathyroid hormone (PTH) secretion in response to changes of extracellular Ca concentration. CaSR is expressed in several tissues including the kidneys and bones in addition to the parathyroid glands. Mutations in CaSR result in several disorders with abnormal calcium metabolism indicating that CaSR is essential for the maintenance of calcium homeostasis. It has been shown that CaSR is involved in other biological processes such as differentiation of keratinocytes, function of the gastrointestinal tract and insulin secretion. However, it remains to be established how important CaSR is in physiological functions. | |