| Theme | The frontier of space medicine | |
|---|---|---|
| Title | Estimation of carcinogenesis risk after exposure to cosmic radiation | |
| Publish Date | 2017/07 | |
| Author | Shizuko Kakinuma | Department of Radiation Effects Research, National Institutes of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology |
| Author | Takamitsu Morioka | Department of Radiation Effects Research, National Institutes of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology |
| [ Summary ] | One of the major concerns for human health during prolonged stay in space environment is the carcinogenic and trans-generational effects after exposure to the radiation in space. Characteristic of space radiation are mixed radiation of proton, neutron, and heavy particle, and long-term radiation exposure at a low dose rate. Since long-term stay in space environment is becoming a reality, it is essential to elucidate the influence of exposure to cosmic radiation. Here, we introduce and discuss topics such as natural radiation exposure on ground, epidemiological survey of atomic-bomb survivors, and health survey in high background radiation areas. Thereafter, our animal carcinogenesis studies are discussed, such as risk analysis of rat breast cancer induced after carbon ion irradiation, genomic mutation analysis of mouse thymic lymphoma induced after carbon ion irradiation, and histopathological analysis of mouse tumor generated after iron ion irradiation. |
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