| Theme | Dialysis related amyloidosis and associated bone and joint disorders | |
|---|---|---|
| Title | Mechanism of β2-microglobulin amyloid fibril formation | |
| Publish Date | 2016/07 | |
| Author | Daisaku Ozawa | Life Science Unit, Tenure-Track Program for Innovative Research, University of Fukui |
| Author | Tadakazu Okoshi | Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui |
| Author | Kazuhiro Hasegawa | Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui |
| Author | Hironobu Naiki | Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui |
| [ Summary ] | β2-Microglobulin (β2MG) is a relatively small globular protein implicated in amyloid fibril formation in patients with dialysis-related amyloidosis. β2MG can also form amyloid fibrils in vitro. The details of the mechanisms associated with β2MG amyloid fibril formation at the molecular level are becoming clear from in vitro studies using biochemical and biophysical methods. It has been shown that biomolecules related to dialysis-related amyloidosis affect β2MG amyloid fibril formation. Exploring the biomolecules which promote or inhibit β2MG amyloid fibril formation, as well as elucidating their mechanisms is essential for developing prophylaxis and therapeutics for dialysis-related amyloidosiscare. Recent studies of β2MG amyloid fibril formation and its inhibition through by the interactions between β2MG and various biomolecules in vitro are reviewed. | |