| Theme | Iron and bone metabolism | |
|---|---|---|
| Title | Pathophysiology of iron-deficiency anemia in chronic kidney disease | |
| Publish Date | 2016/04 | |
| Author | Tatemitsu Rai | Department of Nephrology and Regional Medicine (Ibaraki), Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University |
| [ Summary ] | Anemia is a frequent complication associated with CKD. One common cause of chronic anemia in patients with CKD is iron deficiency. It is important to diagnose iron deficiency because appropriate therapy can potentially treat associated anemia. However, the association between iron deficiency anemia and CV risk has not been adequately investigated. We have recently established a large prospective cohort study of Japanese patients with CKD called the Chronic Kidney Disease Research of Outcomes in Treatment and Epidemiology (CKD-ROUTE) study. We evaluated the baseline characteristics and iron status of CKD-ROUTE participants with or without anemia at enrollment and investigated the association between anemia with iron deficiency and mortality risk over a 24-month follow-up period. We also assessed changes in anemia and iron status after primary management of anemia by nephrologists. Results indicated iron deficiency anemia and isolated anemia were associated with all-cause and CV-related mortality. The absence of relative increase in iron prescriptions suggests that iron deficiency should be accurately assessed and iron supplementation should be used appropriately to manage anemia in non-dialysis patients with CKD. | |