| Theme | Iron and bone metabolism | |
|---|---|---|
| Title | Effects of iron preparations on oxidative stress | |
| Publish Date | 2016/04 | |
| Author | Toru Maruyama | Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University |
| Author | Makoto Anraku | Faculty of Pharmaceutical Sciences, Sojo University |
| Author | Motoko Tanaka | Department of Nephrology, Akebono Clinic |
| [ Summary ] | Iron supplementation is effective in ameliorating anemia in chronic kidney disease (CKD) patients with iron deficiency. However, it has also been demonstrated that intravenous iron injection, especially multiple administration has the potential to induce oxidative stress in conjunction with CKD due to increased hydroxyl radical production attributable to Fenton's reaction. In contrast, ferric citrate formulations, which are oral phosphorus adsorbent, are unlikely to induced oxidative stress in CKD | |