| Theme | Iron and bone metabolism | |
|---|---|---|
| Title | Relationship between iron and FGF23-Klotho system | |
| Publish Date | 2016/04 | |
| Author | Yuichi Takashi | Fujii Memorial Institute of Medical Sciences, Tokushima University |
| Author | Seiji Fukumoto | Fujii Memorial Institute of Medical Sciences, Tokushima University |
| [ Summary ] | Fibroblast growth factor 23 (FGF23) is an essential hormone for phosphate metabolism. It has been shown that intravenous administration of some iron formulations including saccharated ferric oxide, induces hypophosphatemic osteomalacia with high FGF23 levels in patients with iron-deficiency anemia. On the other hand, iron deficiency promotes FGF23 production and induces hypophosphatemia in patients with autosomal dominant hypophosphatemic rickets (ADHR). While iron and FGF23-Klotho system are connected, the detailed mechanisms of this connection remain to be clarified. | |