| Theme | Regeneration of bone and cartilage | |
|---|---|---|
| Title | Local transplantation of peripheral blood stem cells for bone regeneration | |
| Publish Date | 2015/10 | |
| Author | Ryosuke Kuroda | Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author | Takahiro Niikura | Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author | Tomoyuki Matsumoto | Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author | Sangyang Lee | Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| Author | Masahiro Kurosaka | Department of Orthopaedic Surgery, Kobe University Graduate Shool of Medicine |
| [ Summary ] | Whereas most fractures typically heal, a significant proportion (5-10 %) of fractures fail to heal, resulting in delayed union or persistent nonunion. Nonunion of the long bone is a common problem that can be disabling. Treatment may require multiple operative procedures, prolonged hospitalization, and years of disability. Circulating CD34(+) cells, a population rich in endothelial cells and hematopoietic progenitor cells are capable of differentiating into both endothelial cells and osteoblasts. Transplantation of circulating CD34(+) cells provides a favorable environment for fracture healing via angiogenesis/vasculogenesis and osteogenesis, leading finally to functional recovery from fracture. Based on a series of basic studies, we performed a phase 1/2 clinical trial of autologous CD34(+) cell transplantation in patients with tibial or femoral nonunions and reported the safety and efficacy of this novel therapy. In this article, the current concepts and strategies of circulating CD34(+) cellbased therapy for bone repair will be highlighted. | |