| [ Summary ] |
Bone possesses vigorous regeneration activity, as demonstrated by the fracture-healing process. Bone development, repair, and regeneration are regulated by the complex interaction of cells, matrix, and local and systemic hormones or cytokines. A better understanding of the mechanisms of bone development and regeneration is essential in the fields of bone regenerative medicine and bone tissue engineering. This article presents the mechanisms of bone formation, bone induction, fracture healing, and regeneration by bone grafting. |