| Theme | Pediatric bone : From fetus to adolescent | |
|---|---|---|
| Title | Phosphate regulation during childhood and rickets | |
| Publish Date | 2015/07 | |
| Author | Yukihiro Hasegawa | Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center |
| Author | Yoshie Nakamura | Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center |
| Author | Kentaro Miyai | Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center |
| [ Summary ] | Calcium and phosphate account for apprpximately two-thirds of the weight of bone. Most of the phosphate in the body exists within bone as hydroxyapatite. Phosphate in the blood occurs in a free form and is vital in the process of mineralization of the osteoid and growth plates, in conjunction with calcium. Therefore, chronic hypophosphatemia during childhood results in rickets. In this brief review, we discuss the regulation and abnormalities of serum inorganic phosphate concentrations and the pathophysiology and classification of rickets, with a special focus on fibroblast growth factor 23. | |