| Theme | Chronic kidney disease and aging -- Phosphate connection | |
|---|---|---|
| Title | Changes in osteocyte in the field of chronic kidney disease | |
| Publish Date | 2015/01 | |
| Author | Aiji Yajima | Department of Nephrology and Urology, Otsuki Municipal Central Hospital / Department of Medicine, Kidney Center, Tokyo Women's Medical University / Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| Author | Ken Tsuchiya | Department of Medicine, Kidney Center, Tokyo Women's Medical University |
| Author | Masaaki Inaba | Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| Author | Yoshihiro Tominaga | Department of Endocrine Surgery, Nagoya Second Red Cross Hospital |
| Author | Junko Arai | Department of Medicine, Kidney Center, Tokyo Women's Medical University / Department of Nephrology, Otsuki Municipal Central Hospital |
| Author | Yukari Asamiya | Department of Medicine, Kidney Center, Tokyo Women's Medical University |
| Author | Momoyo Omata | Department of Nephrology, Otsuki Municipal Central Hospital |
| Author | Keiko Matsugami | Department of Nephrology, Otsuki Municipal Central Hospital |
| Author | Norio Amizuka | Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| Author | Akemi Ito | Ito Bone Histomorphometry Institute |
| Author | Hironari Shindo | Department of Surgery, Otsuki Municipal Central Hospital / Department of Surgery II, Tokyo Women's Medical University |
| Author | Kosaku Nitta | Department of Medicine, Kidney Center, Tokyo Women's Medical University |
| [ Summary ] | Changes in the osteocyte lacunar wall were first described 40 years ago, however, no further research has been performed on this histomorphometric parameter in the field of chronic kidney disease. Professor Lynda F.Bonewald Ph.D has conducted detailed research on osteocyte and osteocyte biology since 2000, and has published an enormous amount of results that of great interest and surprise to nephrologists during the last 10 years. In the field of chronic kidney disease, the Sherrard's classification has been used and there are only two papers on osteocyte relevant to this field published to this date. Research on products expressed from osteocytes, including FGF-23, sclerostin and RANKL, have been remarkably advanced in this field. In this paper, the changes in osteocyte in the field of chronic kidney disease and the recent publications on osteocytes are discussed. | |