| Theme | Regulation and disorders of calcium and phosphate metabolism | |
|---|---|---|
| Title | New findings concerning FGF23 | |
| Publish Date | 2014/07 | |
| Author | Seiji Fukumoto | Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital |
| [ Summary ] | FGF23 reduces serum phosphate levels by inhibiting proximal tubular phosphate reabsorption and intestinal phosphate absorption through reducing 1,25-dihydroxyvitamin D levels. Excess FGF23 action results in hypophosphatemic diseases such as X-linked hypophosphatemic rickets (XLHR). Recent studies have identified a number of genes as causes of these FGF23-related hypophosphatemic diseases. Anti-FGF23 antibody was shown to improve hypophosphatemia in adult patients with XLHR. In addition, it has been suggested that FGF23 is also involved in calcium reabsorption. Furthermore, many studies have indicated associations between FGF23 levels and various adverse events. However, the mechanisms of these associations are not clear and not all studies revealed these associations. There still remain unanswered questions concerning FGF23. | |