| Theme | Regulation and disorders of calcium and phosphate metabolism | |
|---|---|---|
| Title | Osteocytes : Commander of bone metabolism | |
| Publish Date | 2014/07 | |
| Author | Tomoki Nakashima | Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University / Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO) |
| [ Summary ] | During bone remodeling, resorption by osteoclasts precedes bone formation by osteoblasts. Based on the osteocyte location within the bone matrix and the cellular morphology, it is proposed that osteocytes potentially contribute to the control of bone remodeling by sensing mechanical stress and hormones. Bone has been traditionally regarded as a part of the skeletal and locomotor system, but recent studies suggest that osteocytes regulate systemic biological functions based on an inseparable link between bone and other systems. | |