| Theme | Tumors and bone mineral metabolism | |
|---|---|---|
| Title | Bone metastasis in prostate cancer | |
| Publish Date | 2014/01 | |
| Author | Motohide Uemura | Department of Specific Organ Regulation (Urology), Osaka University Graduate School of Medicine |
| Author | Norio Nonomura | Department of Specific Organ Regulation (Urology), Osaka University Graduate School of Medicine |
| [ Summary ] | Bone metastases are often observed in patients with lung cancer, kidney cancer, breast cancer, myeloma, and prostate cancer. Bone metastases from prostate cancer often exhibit characteristics different from those of the originating organs. For instance, bone is often the only target organ for prostate cancer metastases. Metastatic bone lesions from prostate cancer are more osteoplastic than osteolytic. It is thought that metastatic prostate cancer cells interact specifically with osseous tissue and that this tissue-specific interaction is a critical factor in cancer progression. An understanding of bone metastasis in prostate cancer may lead to novel treatments for the disease. We present the mechanisms which underlie osteoplastic bone metastasis of prostatic origin. | |