| Theme | Parathyroid diseases and their pathogenesis | |
|---|---|---|
| Title | Regulation of parathyroid hormone secretion by calcium and active vitamin D in chronic kidney disease | |
| Publish Date | 2013/11 | |
| Author | Masanori Tokumoto | Department of Medicine, Fukuoka Dental College |
| [ Summary ] | Parathyroid hormone, active vitamin D and fibroblast growth factor 23 function cooperatively to mainten calcium and phosphate homeostasis. Secretion of parathyroid hormone is also regulated by calcium, phosphorus, active vitamin D, as well as fibroblast growth factor 23, suggesting the existence of secure feedback mechanisms for calcium and phosphate homeostasis. Although phosphate-sensing mechanisms remain unknown, the parathyroid hormone-regulating factors, described above, act via specific receptors, such as calcium-sensing receptor, vitamin D receptor, fibroblast growth factor receptor, as well as klotho in the parathyroid gland. Abnormalities in both parathyroid hormone-regulating factors and receptors in the parathyroid gland contribute to disturbances in the feedback mechanism for regulation of parathyroid hormone secretion. This leads to the onset and development of secondary hyperparathyroidism in chronic kidney disease. |
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