| Theme | Regulation, disease states and drug targets of kidney tubular transporters -- Topics | |
|---|---|---|
| Title | Sodium transport and hypertension | |
| Publish Date | 2013/08 | |
| Author | Yuichi Inoue | Department of Nephrology, Tokyo Medical and Dental University |
| Author | Shinichi Uchida | Department of Nephrology, Tokyo Medical and Dental University |
| [ Summary ] | Increased Na-Cl absorption in the kidneys causes hypertension. Pseudohypoaldosteronism type 2 and Liddle's syndrome are hereditary hypertensive diseases characterized by increased Na-Cl reabsorption in the kidneys. Activation of the WNK-OSR1/SPAK-NCC cascade has been identified as the cause of hypertension in association with PHA II. This cascade is regulated by aldosterone and insulin. Impaired Nedd4-2 mediated ENac ubiquitination is identified as the cause of hypertension in Liddle's syndrome. This WNK-OSR 1/SPAK-NCC cascade is a potential target for anti-hypertensive drugs. | |