| Theme | Regulation, disease states and drug targets of kidney tubular transporters -- Topics | |
|---|---|---|
| Title | Uric acid transport and gout | |
| Publish Date | 2013/08 | |
| Author | Naohiko Anzai | Department of Phamacology and Toxicology, Dokkyo Medical University School of Medicine |
| Author | Promsuk Jutabha | Department of Phamacology and Toxicology, Dokkyo Medical University School of Medicine |
| [ Summary ] | Gout is a painful form of inflammatory arthritis, caused by hyperuricemia. Since the kidneys play a dominant role in maintaining serum urate levels through excretion, understanding renal urate transport, mediated by several transporters such as URAT1 and URATv1, is important. Recently, several genome-wide association studies (GWAS) have revealed close associations between serum urate levels and single nucleotide polymorphisms (SNPs) in ten genetic loci including eight transporter-related genes. The transport system for urate related to gout and the possibility of developing new uricosuric drugs are described. | |