| Series | Clinical Investigation | |
|---|---|---|
| Title | Long-term treatment with cinacalcet and lanthanum carbonate to prevents vascular calcification in hemodialysis patients | |
| Publish Date | 2013/01 | |
| Author | Kunihiko Yoshiya | Department of Nephrology, Hara Genitor-Urinary Hospital |
| Author | Masahiro Tsukuda | Department of Nephrology, Hara Genitor-Urinary Hospital |
| Author | Tomihiko Yasufuku | Department of Urology, Hara Genitor-Urinary Hospital |
| Author | Shouji Hara | Department of Urology, Hara Genitor-Urinary Hospital |
| [ Summary ] | Vascular calcification contributes to cardiovascular disease in hemodialysis patients. Adjusting serum levels of phosphate and calcium as well as PTH to keep them within target ranges decreases mortality rates in these patients. However, when conducting conventional treatment, it is difficult to prevent progression of vascular calcification and also difficult to maintain bone mineral density within normal ranges for hemodialysis patients. We evaluated the effects of long-term treatment employing a combination of cinacalcet and lanthanum carbonate for 26 patients with severe secondary hyperparathyroidism over a 3.6 year time period. Twenty-two patients achieved guideline target ranges in regard to serum phosphate, calcium and PTH levels. Deterioration of vascular calcification was significantly prevented in the third year. These results seem to suggest a degree of synergy between cinacalcet and lanthanum carbonate. However, bone mineral density did not improve with this treatment. It is suggested that there is a possibility of improving progression of vascular calcification in hemodialysis patients by using cinacalcet and lanthanum carbonate. It is necessary to examine whether this treatment will lead to improved diagnoses. |
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