| Theme | Physiological roles of phosphorus in nutritional science | |
|---|---|---|
| Title | Phosphorus and bone metabolism | |
| Publish Date | 2013/01 | |
| Author | Mayu Haraikawa | Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University |
| Author | Masae Goseki-Sone | Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University |
| [ Summary ] | Alkaline phosphatase (ALP, EC 3.1.3.1) hydrolyzes a variety of monophosphate esters into inorganic acids and alcohol. Human ALPs are classified into four types : tissue-non specific liver/bone/kidney (TNSALP), intestinal, placental, and germ cell types. Bone-specific ALP is one important bone formation marker. Recent studies have revealed that bone-specific ALP is indispensable for bone mineralization because it controlls concentrations of inorganic pyrophosphates, a potent calcification inhibitor. In this review, we describe the role of "ALP in phosphate metabolism" in relation to skeletal metabolism. | |