| [ Summary ] |
Osteoporosis is a diseases condition in that fracture risk is high due to increased bone fragility regardless of its cause. On the other hand, CKD-MBD is a disorder of systemic mineral metabolism associated with chronic kidney disease. Related bone diseases are not necessarily associated with deteriorations in the mechanical properties of bone tissue. Both factors occur in association with primary osteoporosis. Conditions specific to CKD affect bone strength in CKD patients. Therefore, hip fracture risk be-comes considerably higher among dialysis patients than in the general population. This condition has little to do with systemic mineral metabolism. It is independent from CKD-MBD, and thus may be considered to be a disease condition termed "uremic osteoporosis". Muscle weakness may also account for the increased risk of hip fractures. Thus, further studies are needed to establish preventive strategies. |