| Theme | Recent advances in research concerning FGF23 and Klotho | |
|---|---|---|
| Title | Klotho and energy metabolism | |
| Publish Date | 2012/01 | |
| Author | Satoko Osuka | Department of Oral Medicine, Infection α Immunity, Harvard School of Dental Medicine |
| Author | Junko Akiyoshi | Department of Oral Medicine, Infection α Immunity, Harvard School of Dental Medicine |
| Author | Mutsuko Ohnishi | Department of Oral Medicine, Infection α Immunity, Harvard School of Dental Medicine |
| Author | Takashi Taguchi | Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences |
| Author | Mohammed S. Razzaque | Department of Oral Medicine, Infection α Immunity, Harvard School of Dental Medicine |
| [ Summary ] | α-klotho is a multifunctional protein expressed primarily in the kidneys, parathyroid gland and brain. Low level of α-klotho expression has also been reported in adipogenic cells. Recent studies have found the potential role of α-klotho in the adipose tissue formation and glucose metabolism. Further comprehensive understanding of the relationship between α-klotho and β-klotho in fat-cell turnover, and energy metabolism may lead to the discovery of a novel therapeutic strategy to reduce obesity and its related complications. Based on recent experimental observations, this article will briefly illustrate the potential effect α-klotho on adipogenesis and systemic glucose metabolism. | |