| Theme | Recent advances in research concerning FGF23 and Klotho | |
|---|---|---|
| Title | Mechanisms of Pi homeostasis by FGF23 | |
| Publish Date | 2012/01 | |
| Author | Shinsuke Kido | Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author | Shoji Kuwahara | Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author | Kengo Nomura | Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author | Akiko Ohi | Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author | Sawako Tatsumi | Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author | Hiroko Segawa | Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author | Ken-ichi Miyamoto | Department of Molecular Nutrition, University of Tokushima Graduate School |
| [ Summary ] | We summarize information concerning a novel, important Pi-regulating hormone, fibroblast growth factor 23 (FGF23). We also examine information related to the bone-kidney axis which has emerged in the wake of these findings. FGF23 is a hormone which promotes renal Pi excretion by decreasing reabsorption in the proximal tubules while concurrently reducing plasma 1,25(OH)2D3 by both decreasing its biosynthesis and increasing its metabolism. FGF23 down-regulates the expression of both type IIa and type IIc sodium-dependent Pi cotransporters on the apical surface of renal proximal tubular epithelial cells in vivo. The action of FGF23 requires an additional cofactor, klotho, to bind with high affinity and signal efficiently through cognate FGF receptors. Klotho and FGF receptors 1 (IIIc) form a heterodimeric, receptor for FGF23. We also review the physiological roles of FGF23, as well as receptor specificity and mechanisms of action. | |