| Theme | Progress in the management of osteoporosis | |
|---|---|---|
| Title | New approach to osteoporosis treatment by a new type of active vitamin D "eldecalcitol" | |
| Publish Date | 2011/07 | |
| Author | Takami Miki | Gerontology and Neurology, Osaka City University Medical School |
| Author | Hiroyuki Shimada | Gerontology and Neurology, Osaka City University Medical School |
| [ Summary ] | A new type of active vitamin D, known as eldecalcitor, has been shown to be effective in preventing osteoporotic fractures in a double blind study. This vitamin D is significantly more effective in ameliorating metabolic bone markers, increasing bone mineral density and preventing fractures compared to active vitamin D3 (1α‒hydroxyvitamin D3). The anti‒fracturing effect was confirmed in osteoporotic patients with adequate serum 25‒hydroxyvitamin D levels. When this active vitamin D is administered to a range of osteoporotic patients, including elderly patients, adherence will improve. The effectiveness of this agent remains to be clarified not only for premenopausal osteoporosis patients or those with glucocorticoid induced osteoporosis, but also for patients receiving bisphosphonates or SERM treatment. | |