| Series | Case Report | |
|---|---|---|
| Title | A case of short bowel syndrome with relative hypoparathyroidism, reversing parathyroid function by replacements of oral magnesium | |
| Publish Date | 2011/07 | |
| Author | Hitoshi Kato | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Hiroaki Hara | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Minoru Hatano | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Megumi Inamura | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Shinpei Okazaki | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Tota Kiba | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Tokushi Nakajima | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Taisuke Shimizu | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Mizuki Iwanaga | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Takatsugu Iwashita | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Yusuke Tayama | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Juko Asakura | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Chie Noiri | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Tomoya Ogawa | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Akihiko Matsuda | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Koichi Kanozawa | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Hajime Hasegawa | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Tetsuya Mitarai | Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University |
| Author | Satoko Nakamura | Sekishin Clinic and Sekishindo Hospital |
| Author | Hiroyuki Takao | Sekishin Clinic and Sekishindo Hospital |
| Author | Masaya Murakawa | Sekishin Clinic and Sekishindo Hospital |
| [ Summary ] | A 48‒year‒old woman was admitted to our facility with a diagnosis of lymphoangitis and acute renal failure. She was diagnosed with uterine cancer (stage IIb) at 27 years of age, and received a total uterectomy and radiotheray. At 46 years of age, she had an extensive colon excision due to adhesion related colitis and difficulty with treatments. Laboratory studies revealed a white blood cell count of 15,600/mm3, CRP of 22.0 mg/dl, serum creatinine of 5.53 mg/dl, correct serum calcium of 5.6 mg/dl, as well as a normal range serum PTH level (whole PTH 38.4 pg/ml). There were lower than normal levels of urinary calcium secretion (10 mg/day) and serum magnesium levels (0.6 mg/dl). She experienced resistance to calcium replacement therapy and active vitamin D therapy. She developed hypo‒magunesemia, because of the link between relative hypoparathyroidism and hypocalcaemia. She immediately attained normal calcium concentrations, after the administration of oral magnesium （magnesium oxide） replacement therapy. Magnesium regulates the secretion of PTH in parathyroid cells. It also mediates calcium‒sensing receptors in the membranes of parathyroid cells. Hypo‒magnesemia may induce the down‒regulation of PTH secretion by calcium‒sensing receptors, which leads to hypocalcemia. | |