| Theme | New era of the vitamin K research in bone metabolism | |
|---|---|---|
| Title | Novel actions of vitamin K | |
| Publish Date | 2011/07 | |
| Author | Kuniko Horie‒Inoue | Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University |
| Author | Satoshi Inoue | Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University / Departments of Anti‒Aging Medicine, Graduate School of Medicine, The University of Tokyo |
| [ Summary ] | Vitamin K exerts various actions mediated through pathways other than GGCX‒dependent one, such as through nuclear receptor‒dependent transcriptional regulation and protein kinase‒dependent pathways. Nuclear steroid and xenobiotic receptor (SXR) or pregnane X receptor (PXR) has been shown to contribute to bone metabolism by regulating expression of their target genes. Protein kinase‒mediated vitamin K action has been reported to be associated with anti‒tumor effects as well as bone metabolism. Development of new vitamin K‒related drugs may be possible by modulating individual vitamin K‒dependent pathways. | |