| Theme | Bone metabolism in rheumatoid arthritis | |
|---|---|---|
| Title | Bone formation and resorption in rheumatoid arthritis | |
| Publish Date | 2010/10 | |
| Author | Fumitaka Mizoguchi | Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University |
| Author | Hitoshi Kohsaka | Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University |
| [ Summary ] | Rheumatoid arthritis (RA) is a systemic disorder characterized by chronic polyarthritis and progressive destruction of cartilage and bone. Excess bone resorption by activated osteoclasts is a hallmark of the pathogenesis of RA. Furthermore, bone formation activities of osteoblasts are suppressed, which contributes to the destruction of joint structures. Recent studies have disclosed the rough outlines of bone formation and resorption in rheumatoid arthritis. Further progress is expected to protect from bone destruction and to repair damaged joints in RA. | |