| Series | Clinical Investigation | |
|---|---|---|
| Title | The postmenopausal osteoporosis in patients on chronic hemodialysis | |
| Publish Date | 2010/07 | |
| Author | Osamu Saito | Division of Nephrology, Department of Medicine, Jichi Medical University |
| Author | Takako Saito | Division of Nephrology, Department of Medicine, Jichi Medical University |
| Author | Shinji Asakura | Suginoki Clinic |
| Author | Eiji Kusano | Division of Nephrology, Department of Medicine, Jichi Medical University |
| [ Summary ] | Bone fractures are not caused entirely by secondary hyperparathyroidism in chronic hemodialysis patients. Other factors may be involved in these patients' fractures. The aim of this study was to evaluate the effect of osteoporosis on bone density in hemodialysis patients. A total of 150 adult patients (97 male and 53 female) were enrolled in this prospective observation for one year, from August 2007 to July 2008. Episodes of bone fractures were assessed. NTx, BAP, and iPTH were also evaluated. Eight patients (5.3%) had bone fractures. NTx levels were elevated in these patients. In female dialysis patients, there were significant correlations between age and NTx levels. However, no correlation was seen in male patients. The levels of NTx gradually increased in female patients over 50 years old. The maximum values were seen in those who were 70 years old. There was no correlation between age and NTx levels in female dialysis patients. In conclusion, low bone density for postmenopausal osteoporosis may be involved in bone fractures in female hemodialysis patients. This study indicates that NTx levels may be an effective marker for postmenopausal osteoporosis in chronic hemodialysis patients. |
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