| Theme | Magnesium and chronic kidney disease | |
|---|---|---|
| Title | Regulatory mechanisms controlling serum magnesium concentrations in chronic kidney disease | |
| Publish Date | 2010/07 | |
| Author | Akira Ishii | Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| Author | Yasuo Imanishi | Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] | Magnesium (Mg) is the main intracellular divalent cation, and plays important roles in homeostasis as a co-factor of enzymes. Serum Mg concentrations are regulated by absorption in the intestines, excretion from the kidneys and mobilization from bone and other tissues. In chronic kidney disease (CKD) urinary Mg excretion may be insufficient to balance intestinal Mg absorption. Dietary Mg intake then becomes a major determinant of serum Mg levels. Mg has also been linked to bone and lipid metabolism, cardiovascular diseases, vascular calcification and atherosclerotic vascular disease. | |