| Theme | Intestinal tract and bone mineral metabolism | |
|---|---|---|
| Title | Pathophysiology of electrolyte disorders in short bowel syndrome | |
| Publish Date | 2010/04 | |
| Author | Yosuke Ono | Division of Endocrinology and Metabolism, Department of Medicine, National Defense Medical College |
| Author | Yuji Tanaka | Division of Endocrinology and Metabolism, Department of Medicine, National Defense Medical College |
| [ Summary ] | Short bowel syndrome is defined as a condition related to malabsorption and malnutrition resulting from the loss of absorptive area after massive small bowel resection. The metabolic complications after small bowel resection depend on a number of factors, including the extent and site of intestinal resection, presence or absence of the ileocecal valve and functional capacity of the remaining small intestine and colon. The severity of clinical features varies from patient to patient. Hypomagnesemia is common and is treated with oral or intravenous magnesium supplements. Magnesium deficiency occurs due to reduced absorption because of chelation with unabsorbed fatty acids in the bowel lumen and because of increased renal excretion. Insufficient PTH secretion and its effects on bone and the kidnies due to hypomagnesemia results in hypocalcemia. Patients need long-term frequent nutritional monitoring and care to prevent disorders associated with malabsorption. |
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