| Theme | Intestinal tract and bone mineral metabolism | |
|---|---|---|
| Title | Inorganic phosphate metabolism and small intestine | |
| Publish Date | 2010/04 | |
| Author | Sawako Tatsumi | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| Author | Satoko Kikui | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| Author | Etsuyo Hanafusa | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| Author | Shinsuke Kido | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| Author | Ken-ichi Miyamoto | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| [ Summary ] | Intestinal phosphate absorption plays an important role in phosphate homeostasis. Phosphate absorption occurs through two pathways. One is a paracellular mechanism involving tight junctions. The other is an active transcellular mechanism involving the type II sodium-dependent phosphate cotransporter (NPT2b). Intestinal NPT2b is known to be regulated by 1,25(OH)2D3, phosphaturic hormone FGF23 and dietary phosphate. In addition, providing high phosphorous diets stimulates the secretion of intestinal phosphaturic factors. The factors cause an increase in urinary phosphate excretion, and control serum phosphate levels. These results suggest that a phosphate sensor may be present in the small intestine. | |