| Theme | Phosphate regulatory system and disorder in phosphate homeostasis | |
|---|---|---|
| Title | Role of intestines in phosphate homeostasis | |
| Publish Date | 2009/10 | |
| Author | Yutaka Taketani | Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School |
| Author | Yuichiro Takei | Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School |
| Author | Hironori Yamamoto | Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School |
| Author | Eiji Takeda | Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School |
| [ Summary ] | Intestinal phosphate absorption comprises an important element in the mechanisms for adapting dietary phosphate changes. TypeIIb and TypeIII sodium dependent phosphate transporters (NaPi) are expressed in the small intestine. However, type IIb NaPi (NaPi-IIb) performs a key role in intestinal phosphate absorption. Most phosphate regulating factors such as vitamin D, play key rolls in regulating the expression of NaPi-IIb via genomic or nongenomic mechanisms. In addition, dietary phosphate can also regulate the expression of NaPi-IIb without those factors. These findings suggest that a "phosphate sensor" may exist in the small intestine. | |