| Theme | Beyond bone mineral density : roles of collagen and its related mineral quality in bone fragility in osteoporosis, diabetes, and renal dysfunction | |
|---|---|---|
| Title | Pentosidine as candidate for bone quality marker associated with fracture risk | |
| Publish Date | 2009/07 | |
| Author | Masahiro Yamamoto | Internal Medicine 1, Shimane University Faculty of Medicine |
| [ Summary ] | Bone strength reflects the integration of bone mineral density and bone quality, the latter of which consists of both structural properties and material properties. Increases in quantities of pentosidine in bone collagen deteriorate bone strength, suggesting that high levels of pentosidine in bone lead to fragility. Blood levels of pentosidine are correlated with bone content. Blood and urinary levels of pentosidine are associated with increased risk of vertebral fractures in patients with postmenopausal type 2 diabetes and primary osteoporosis. These results suggested that blood or urinary levels of pentosidine are useful markers for predicting the risk of vertebral fractures. | |