| Theme | Beyond bone mineral density : roles of collagen and its related mineral quality in bone fragility in osteoporosis, diabetes, and renal dysfunction | |
|---|---|---|
| Title | Bone metabolism disorders and collagen cross-links in CKD patients | |
| Publish Date | 2009/07 | |
| Author | Jun Mitome | Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| Author | Hiroyasu Yamamoto | Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| [ Summary ] | CKD patients have a number of risk factors which reduce bone mineral density such as aging, menopause, diabetes mellitus, and corticosteroid use. Furthermore, bone metabolism disorders induced by secondary hyperparathyroidism are major causes of bone fragility, and increase the incidence of bone fractures in CKD patients. Recently, attention has been paid to the deterioration of not only bone mineral density but also bone quality as risk factors for bone fractures. It has been revealed that aging and oxidative stress results in the formation of advanced glycation endproducts (AGEs), which affects bone collagen cross-links. In addition, inhibition of enzyme activity in lysyle-oxidase, due to hyperhomocysteinemia with renal dysfunction, potentially decreases bone quality. | |