| Theme | Recent progress in calcium/phosphate metabolism and Klotho | |
|---|---|---|
| Title | Klotho and regulation of phosphate homeostasis | |
| Publish Date | 2009/04 | |
| Author | Hiroko Segawa | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| Author | Ichiro Kaneko | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| Author | Ken-ichi Miyamoto | Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School |
| [ Summary ] | Inorganic phosphate （Pi） is an essential nutrient in terms of both cellular metabolism and skeletal mineralization. Dietary Pi is absorbed by the intestine, deposited in the bone and filtered by the kidney. Regulation of Pi absorption/reabsorption is achieved by changing the apical abundance of Na/Pi transporters (NaPi-IIa, IIb, and IIc). The regulatory mechanisms involve several signaling factors, such as fibroblast growth factor (FGF) 23. FGF23, produced in the osteocytes, which binds with FGF receptor (FGFR) and klotho in target organs (kidney or parathyroid grand etc.) acting as a Pi regulating factor. | |