| Theme | Recent progress in calcium/phosphate metabolism and Klotho | |
|---|---|---|
| Title | Mechanism of fibroblast growth factor 23 secretion | |
| Publish Date | 2009/04 | |
| Author | Yuichiro Shimizu | Division of Nephrology and Endocrinology, Department of Medicine, University of Tokyo Hospital |
| Author | Seiji Fukumoto | Division of Nephrology and Endocrinology, Department of Medicine, University of Tokyo Hospital |
| [ Summary ] | FGF23 is a humoral factor that is produced by osteocytes and reduces serum phosphate as well as 1,25-dihydroxyvitamin D levels by acting on the kidnies through some FGF receptor and the Klotho. It has been shown that hypophosphatemic rickets/osteomalacia is caused by excess FGF23 activity. In contrast, deficient FGF23 activity may cause hyperphosphatemic tumoral calcinosis. Results indicate that the production and circulatory levels of FGF23 are tightly regulated. However, detailed mechanisms of this regulation remain to be clarified. |
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