| Series | ［Series］Case Report | |
|---|---|---|
| Title | Deterioration of renal function through hypercalcemia induced by vitamin D compound intoxication in CKD patients | |
| Publish Date | 2009/01 | |
| Author | Kunihiko Yoshiya | Department of Nephrology, Hara Genito-urinary Hospital |
| Author | Masafumi Kumano | Department of Urology, Hara Genito-urinary Hospital |
| Author | Shouji Hara | Department of Urology, Hara Genito-urinary Hospital |
| Author | Nobutoshi Oka | Department of Urology, Hara Genito-urinary Hospital |
| [ Summary ] | Six elderly CKD patients were given vitamin D compounds in relation to diagnoses of osteoporosis and lumbago. As a result, they developed hypercalcemia, and exhibited symptoms of aggravated renal function. Blood examination findings at initial diagnosis were BUN 48.1 mg / dl, Cr 301 mg / dl, Ca 12.7 mg / dl. In spite of slight abnormal urinary findings, renal dysfunction was grave. A characteristic of the diagnoses was the presence of hypercalcemia and renal dysfunction. After drug withdrawal, the laboratory findings were restored in BUN 21.6 mg / dl, Cr 1.55 mg / dl, Ca 9.6 mg / dl. The mechanism of renal function deterioration was regarded to be bypercalcemic nephropathy. Hypercalcemia was induced by vitamin D intoxication. At withdrawal of vitamin D compounds, hypercalcemia and renal dysfunction improved. It is necessary to note that there is a risk of exacerbated renal function in elderly CKD patients through administration of vitamin D compounds. | |