| Theme | Dialysis related amyloidosis -- The breakthrough is close at hand | |
|---|---|---|
| Title | Direct hemoperfusion beta2-m adsorption column | |
| Publish Date | 2009/01 | |
| Author | Takaya Abe | Division of Nephrology and Kidney Center, Kobe University School of Medicine |
| Author | Masafumi Fukagawa | Division of Nephrology and Kidney Center, Kobe University School of Medicine |
| [ Summary ] | The beta2-m adsorption column of the direct hemoperfusion (Lixelle) contains porous cellulose adsorbent beads, in which a hexadecyl group with high hydrophobicity is used as ligand porous cellulose adsorbent beads. It incorporates peptides and proteins with molecular weights of 4,000 to 20,000 by employing the molecule sieving effect on the surface pores of tbe beads. It adsorbs only hydrophobic proteins, such as beta2-m, by binding with the hydrophobic hexadecyl hydrocarbonate group. Some previous studies have reported that the use of Lixelle improved clinical symptoms such as decreases in the frequency of nocturnal awakening, joint pain severity, and the improving joint mobility, other parameters, such as pinch strength, and the median motor terminal latency, and the questionnaire concerning ADL, in dialysis-related amyloidosis patients. |
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