| Theme | Dialysis related amyloidosis -- The breakthrough is close at hand | |
|---|---|---|
| Title | Regulatory mechanisms of inflammatory bone resorption in osteoclast differentiation and function | |
| Publish Date | 2009/01 | |
| Author | Masanori Koide | Institute for Oral Science, Matsumoto Dental University |
| Author | Nobuyuki Udagawa | Institute for Oral Science, Matsumoto Dental University / Department of Biochemistry, Matsumoto Dental University |
| [ Summary ] | Osteoclast differentiation is tightly regulated by osteoblasts. Osteoblasts express two cytokines, M-CSF and RANKL, essential for osteoclast differentiation. Osteoclast precursors firstly differentiate into mononuclear osteoclasts in response to M-CSF and RANKL. NFATcl is a transcription factor, which is involved in the determination of osteoclast differentiation. NFATcl is activated by calcium oscillations. Calcium channels have an effect on calcium oscillations. Calcium channels can also play a role in osteoclast differentiation and function. The application of calcium channel inhibitors may be a new therapeutic strategy for the treatment of local bone resorption induced by inflammatory disease. |
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