| Series | ［Series］Clinical Investigation | |
|---|---|---|
| Title | Efficacy of 1-84 PTH assays in uremic patients with secondary hyperparathyroidism who have undergone PTx | |
| Publish Date | 2008/07 | |
| Author | Susumu Matsuoka | Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital |
| Author | Yoshihiro Tominaga | Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital |
| Author | Nobuaki Uno | Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital |
| Author | Tetsuhiko Sato | Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital |
| [ Summary ] | [Background] 1-84 PTH assays detect full length PTH peptides and allow for precise diagnosis of abnormal PTH secretion. [Purpose] The present study was designed to clarify the efficacy of 1-84 PTH assays for uremic patients with secondary hyperparathyroidism (2HPT) who have undergone parathyroidectomy (PTx). [Subjects and Method] Seventy patients who underwent initial PTx were enrolled in this study. We measured serum PTH levels through intact PTH assays and whole PTH assays capable of detecting circulating 1-84 PTH peptides before and after PTx (day 1). We also measured PTH levels through the intact PTH assays 1 month and 3 months after PTx. We also analyzed the ratio of whole PTH to intact PTH and explored the relationship of that ratio with the total weight of parathyroid glands at the time of PTx. [Result] The total weight of parathyroid glands correlated negatively with the ratios of whole PTH to intact PTH levels (r = -0.287, p = O.O165). Interestingly, that whole-intact PTH ratio had a negative relationship with preoperative intact PTH (r = -0.341, p = 0.0040). [Conclusion]As the total weight of parathyroid glands increased, intact PTH increased, and the whole PTH / intact PTH ratio decreased. Taken together, parathyroid gland growth may negatively regulate fragment PTH / full-length PTH secretion in 2HPT. | |