| Theme | Osteocyte | |
|---|---|---|
| Title | Physiologic function of osteocytes | |
| Publish Date | 2008/07 | |
| Author | Kyoji Ikeda | National Center for Geriatrics and Gerontology (NCGG) |
| [ Summary ] | Osteocytes are the most numerous and longest lived cells in bone tissue. However, compared to osteoclasts and osteoblasts, their physiologic function remains elusive. A transgenic mouse model which enables inducible ablation of osteocytes was established. It was determined that the osteocyte network serves important physiologic functions in mechanotransduction, mineralization, osteoclast recruitment and repair of microdamage. | |