| Theme | Osteocyte | |
|---|---|---|
| Title | Microscopic observation on osteocyte lacunar-canalicular system in bone | |
| Publish Date | 2008/07 | |
| Author | Norio Amizuka | Center for Transdisciplinary Research, Niigata University |
| Author | Sobhan Ubaidus | Center for Transdisciplinary Research, Niigata University |
| Author | Taku Kojima | Center for Transdisciplinary Research, Niigata University |
| Author | Paulo HL Freitas | Center for Transdisciplinary Research, Niigata University |
| Author | Li Mingi | Center for Transdisciplinary Research, Niigata University |
| Author | Junko Shimomura | Division of Pediatric Dentistry, The Nippon Dental University School of Life Dentistry at Niigata |
| [ Summary ] | Osteocytes are cells embedded in the bone matrix that perform numerous cytoplasmic processes, and form a cellular network referred to as an “osteocytic lacunar-canalicular system” (OLCS). The OLCS is involved in ionic transport, mechanical load sensing, and regulation of bone remodeling. The OLCS in immature bone (woven bone) is irregularly arranged. However, as the bone becomes more compact and changes into the lamellar type, the OLCS becomes well arranged. Bone remodeling is believed to be responsible for the dynamic reorganization of the OLCS. A clear example of a well organized OLCS can be seen in the osteons (Haversian system) of cortical bones, and in BSU (basic structural units) of the trabeculae. The histology and ultrastructural aspects of OLCS are briefly reviewed. | |