| Theme | Cinacalcet hydrochloride | |
|---|---|---|
| Title | Effects of cinacalcet hydrochloride on secondary hyperparathyroidism | |
| Publish Date | 2008/04 | |
| Author | Jun Mitome | Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei School of Medicine |
| Author | Hiroyasu Yamamoto | Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei School of Medicine |
| [ Summary ] | Secondary hyperparathyroidism (2HPT) is one of common complication in patients with chronic kidney disease. 2HPT not only elevaties plasma PTH, but also increases calcium-phosphorus product levels and vascular calcification, which are associated with cardiovascular morbidity and mortality. Cinacalcet hydrochloride is a calcimimetic agent that acts as an allosteric modulator of the calcium-sensing receptor present on the surface of parathyroid cells. By targeting the calcium-sensing receptor, cinacalcet provides a new means of regulating PTH secretion by amplifying the receptors' sensitivity to extracelluar calcium and reducing PTH concentrarions. Recently, several clinical trials have demonstrated that cinacalcet hydrochloride is useful to reduce plasma PTH, Ca and P levels. Accordingly, cinacalcet HC1 has received attention as a new strategy for 2HPT treatment. |
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