| [ Summary ] |
Hypophosphatemia is caused by impaired intestinal phosphate absorption, a shift of phosphate into the intracellular pool or bones, as well as reduced proximal tubular phosphate reabsorption. Fibroblast growth factor (FGF) 23 has recently been shown to work as a phosphate-regulating hormone. Several hypophosphatemic diseases, including hypophosphatemia after renal transplantation, have been shown to be caused by excess FGF23 actions. Although current therapies for hypophosphatemia remain largely symptomatic, it is desirable to establish new strategies for hypophosphatemia, based on disease etiologies. |