| [ Summary ] |
Phosphate homeostasis is mainly regulated by the kidnies, the bones, and the intestines. Renal proximal reabsorption of phosphate is regulated by controlling the amount of NaPi-II a, NaPi-II c cotransporters in the brush border membrane of the proximal tubules. NaPi cotransporters are regulated by the parathyroid hormone (PTH) and vitamin D. Intestinal reabsorption of phosphate is regulated by NaPi-II b. Recently, fibroblast growth factor 23 (FGF23) has been cloned. In this review, we discuss the regulation of NaPi proteins, and their physiological role. |