| [ Summary ] |
In wealthy, aging societies, the number of lifestyles-related diseases such, as obesity and osteoporosis, have been increasing rapidly. Current lifestyles in many countries initiate obesity, especially visceral fat accumulation, and lead to the onset of metabolic syndromes, such as cardiovascular events, hyperlipidemia and diabetes mellitus, based on insulin resistance. Several studies of adipocyte function have revealed that adipose tissue is not merely an energy storing organ but secretes a variety of biologically active molecules, conceptualized as “adipocytokines”. These include tumor necrosis factor-α, estrogen, leptin and adiponectin. Abnormal secretion of these adipocytokines is also thought to cause metabolic syndromes. Adipocytes exist not only in visceral and subcutaneous tissue but also in bone marrow. Therefore, it is important to know their effects not only on glucose and lipid metabolism but also on bone metabolism. This report aims to review some of the effects of visceral fat accumulation on bone metabolism. |