| [ Summary ] |
Insulin resistance, which is critically involved in the development of metabolic syndrome, is one of the most significant risk factors for cardiovascular events through the progression of atherosclerosis. Recent investigations demonstrate that, in addition to mineral metabolism and endocrine system, the sympathetic nervous system and glucose and lipid metabolism play important roles in the regulation of bone metabolism. Thus, insulin resistance and / or metabolic syndrome are emerging issues in metabolic bone diseases, such as osteoporosis. Further more, there may be an intimate relationship between bone metabolism and atherosclerosis, since it has been acknowledged that severe atherosclerosis is common in patients with osteoporosis. Insulin resistance may be a crucial factor not only in atherosclerosis but also osteoporosis. |