| Theme | New aspect of calcium, magnesium and phosphate transport -- Basic principles and clinical applications | |
|---|---|---|
| Title | Roles of fibrobrast growth factor 23 and klotho on the regulation of type II sodium dependent phosphate transporters | |
| Publish Date | 2007/01 | |
| Author | Hiroko Segawa | Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author | Akemi Onizuka | Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author | Yuka Tomoe | Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author | Ken-ichi Miyamoto | Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| [ Summary ] | The present study demonstrated that hyperphosphatemia in kl / kl mice results from increased renal sodium-dependent Pi transporter activity and increased intestinal Pi absorption. Mutation of klotho causes an elevation in the type II a and type II c Na / Pi cotransporter proteins in the apical membrane, but this elevation cannot be explained by changes in FCF23, kl / kl mice may provide an important tool to study the roles of FGF23 in body Pi homeostasis. | |